2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

Related Products

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-I0678S1
    Regorafénib N-oxyde (M2)-13C,d3
    Regorafénib N-oxyde (M2)-13C,d3 is the 13C- and deuterium labeled Regorafénib N-oxyde (M2). Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/Flt-1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively.
    Regorafénib N-oxyde (M2)-<sup>13</sup>C,d<sub>3</sub>
  • HY-123006
    Aszonalenin
    Aszonalenin is a metabolite of Aspergillus zonatus.
    Aszonalenin
  • HY-137208
    Chondroitin disaccharide Δdi-0S sodium
    Chondroitin disaccharide Δdi-0S sodium is an unsaturated disaccharide produced by the degradation of Chondroitin sulfate (HY-B2162). Chondroitin disaccharide Δdi-0S sodium produces fluorescent pyridylamino derivative with 2-aminopyridine, which can be used in studies about the metabolic pathway of Chondroitin sulfate and related disease mechanisms.
    Chondroitin disaccharide Δdi-0S sodium
  • HY-118517
    α-Hydroxytamoxifen
    α-Hydroxytamoxifen is a metabolite of tamoxifen, reacts with DNA in the absence of metabolizing enzymes, and causes formation of DNA adducts.
    α-Hydroxytamoxifen
  • HY-N12842
    2-Deoxokanshone L
    2-Deoxokanshone L is a degradation product of Nardosinone (HY-N0380).
    2-Deoxokanshone L
  • HY-161479
    Melamine/OVA
    Melamine/OVA is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Melamine/OVA
  • HY-135180
    1H-1-Ethyl Candesartan Cilexetil
    1H-1-Ethyl Candesartan Cilexetil is a potential impurity found in bulk preparations of Candesartan Cilexetil (HY-17505).
    1H-1-Ethyl Candesartan Cilexetil
  • HY-135194
    Risperidone E-oxime
    Risperidone E-oxime is an impurity of Risperidone. Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively .
    Risperidone E-oxime
  • HY-131279
    Olmesartan ethyl ester
    Olmesartan ethyl ester (compound 11) is an Olmesartan impurity. Olmesartan (RNH-6270) is an angiotensin II receptor (AT1R) antagonist used to in the high blood pressure study.
    Olmesartan ethyl ester
  • HY-131272
    Febuxostat dicarboxylic acid impurity
    		98.76%
    Febuxostat dicarboxylic acid impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM.
    Febuxostat dicarboxylic acid impurity
  • HY-158547
    Etherolenic acid
    Etherolenic acid, a divinyl ether oxylipin, is a metabolite of Linolenic acid.
    Etherolenic acid
  • HY-G0022
    Doxorubicinol hydrochloride
    		99.90%
    Doxorubicinol hydrochloride (13-Dihydroadriamycin hydrochloride) is a secondary alcohol metabolite of Doxorubicin.
    Doxorubicinol hydrochloride
  • HY-B1834S1
    Megestrol-d5
    Megestrol-d5 is the deuterium labeled Megestrol. Megestrol is a synthetic progestin and used for the treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with an acquired immunodeficiency syndrome diagnosis[1][2].
    Megestrol-d<sub>5</sub>
  • HY-N7177
    Hydroxytanshinone IIA
    Hydroxytanshinone IIA is a hydroxylated metabolite of Tanshinone IIA. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2/KDR/Flk-1.
    Hydroxytanshinone IIA
  • HY-128459
    N-Demethylerythromycin A
    N-Demethylerythromycin A is a metabolite of Erythromycin A. Erythromycin A is an antibiotic.
    N-Demethylerythromycin A
  • HY-13318R
    Oseltamivir acid (Standard)
    Oseltamivir acid (Standard) is the analytical standard of Oseltamivir acid. This product is intended for research and analytical applications. Oseltamivir acid (GS 4071), the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of influenza virus neuraminidase (IC50=2 nM) with activity against both influenza A and B viruses.
    Oseltamivir acid (Standard)
  • HY-W016498R
    Paraxanthine (Standard)
    Paraxanthine (Standard) is the analytical standard of Paraxanthine. This product is intended for research and analytical applications. Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels.
    Paraxanthine (Standard)
  • HY-B1069R
    Molsidomine (Standard)
    Molsidomine (Standard) is the analytical standard of Molsidomine. This product is intended for research and analytical applications. Molsidomine is an orally available, long-acting vasodilator that is metabolized in the liver to the active metabolite Linsidomine, an unstable compound that releases NO and acts as a vasodilator.
    Molsidomine (Standard)
  • HY-117229
    Sonidegib metabolite M48
    Sonidegib metabolite M48 is the main circulating metabolite of Sonidegib. Sonidegib is a hedgehog pathway inhibitor. M48 showed a much longer Tmax (60 h) than Sonidegib.
    Sonidegib metabolite M48
  • HY-135328
    Norverapamil
    Norverapamil ((±)-Norverapamil), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.
    Norverapamil
Cat. No. Product Name / Synonyms Application Reactivity